About Marburg Virus Disease (MVD):
- MVD is a severe and often fatal hemorrhagic fever caused by the Marburg virus, with no approved vaccines or treatments currently available.
- It was first identified in 1967 in the German city of Marburg. It is named after an outbreak linked to laboratory workers exposed to infected green monkeys imported from Uganda.
- Geographical spread: Most outbreaks have occurred in sub-Saharan Africa, including countries like Tanzania, Uganda, Angola, Ghana, Kenya, and Zimbabwe.
- Transmission: Initially transmitted from fruit bats (Rousettus aegyptiacus) to humans. It can spread occurs through direct contact with bodily fluids of infected individuals or contaminated surfaces.
- Symptoms:
- Early signs: High fever, severe headache, and malaise.
- Advanced stage: Severe bleeding, liver failure, multi-organ dysfunction, shock, and death within 8-9 days of symptom onset.
- Fatality rate: The average case fatality rate is approximately 50%, varying from 24% to 88% depending on the virus strain and case management.
- Diagnosis: Confirmed through RT-PCR (Reverse Transcription Polymerase Chain Reaction) tests and virus isolation procedures that require maximum biohazard containment.
- Treatment: No specific treatment exists. Supportive care includes rehydration, electrolyte replacement, and symptom management, improving survival chances.
- Vaccine development: Promising vaccines, such as the Sabin Vaccine Institute’s single-dose vaccine, are under Phase 2 trials in Uganda and Kenya. Rwanda also received investigational vaccines to support outbreak control.
Key Facts About Rwanda:
- It is a landlocked country in East-Central Africa, referred to as the "Land of a Thousand Hills".
- Borders: Burundi, Tanzania, Uganda, and the Democratic Republic of the Congo.
- Rivers: The Nile and Congo rivers flow through Rwanda.
- Capital City: Kigali.
2. Ocean Anoxic Event 1a (OAE 1a)
About Ocean Anoxic Event 1a (OAE 1a):
- OAE 1a occurred during the Cretaceous Period (145–66 million years ago), marking a time when Earth’s oceans became depleted of oxygen. This led to severe disruptions in marine ecosystems.
- It was triggered by massive volcanic eruptions, which released large amounts of carbon dioxide (CO₂), resulting in global warming and oxygen depletion in the oceans.
- These conditions created anoxic marine basins, where oxygen levels were nearly absent.
- Impacts: The interaction of CO₂ and seawater formed carbonic acid, dissolving marine organisms’ shells and reducing oxygen levels.
- Resulted in the extinction of several marine species, particularly plankton, and led to the formation of black shales, organic carbon-rich layers preserved in geological records.
- Anoxic marine basins: Bodies of water, often in deep ocean regions, where oxygen levels are extremely low or absent.
- Characteristics: Favor the survival of specialized microbes and fungi while inhibiting most aerobic life forms.
- Carbon Sequestration: Low oxygen levels slow the decomposition of organic matter, aiding in long-term carbon sequestration, which helps reduce atmospheric CO₂ levels.
- Examples: Black Sea, Cariaco Basin (Caribbean Sea), and Orca Basin (Gulf of Mexico).
Key Highlights of the Recent Study:
- Timing: The event began 119.5 million years ago, confirmed through isotopic analysis of volcanic tuffs from Japan’s Hokkaido Island.
- OAE 1a lasted approximately 1.1 million years, indicating the extended recovery period for oceans after CO₂-driven warming and anoxia.
- Volcanic activity: Linked to massive volcanic eruptions, such as the Ontong Java Nui complex, which released significant CO₂ into the atmosphere and oceans.
- Modern relevance: Highlights parallels between ancient volcanic CO₂ emissions and current human-induced warming.
- Warns that rapid modern warming could trigger similar disruptions in marine ecosystems and potentially lead to a Holocene extinction event.
3. Gulf Cooperation Council (GCC)
About Gulf Cooperation Council (GCC):
- It is a regional political and economic alliance, established in 1981. It was formed in response to escalating regional tensions, particularly the Iranian Revolution (1979) and the Iran-Iraq War (1980–1988).
- It comprises six Arab states: Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, and the United Arab Emirates (UAE).
Key Features of the GCC:
- The GCC countries together hold almost half of the world’s oil reserves, making them vital players in the global energy market.
- The GCC convenes yearly summits to discuss strategies for cooperation and regional stability.
Organizational Structure of the GCC:
- Supreme council:
- Highest authority: Composed of the heads of state from all member countries.
- Decision-making: Decisions are made through unanimous approval.
- Presidency rotation: The presidency rotates annually, based on the alphabetical order of member states.
- Ministerial council:
- Composed of foreign ministers or their representatives from member states.
- Role: Proposes policies and implements decisions of the Supreme Council.
- Meetings: Held every three months.
- Secretariat general:
- Acts as the administrative arm of the GCC.
- Functions: Monitors policy implementation and arranges meetings.
- Headquarters: Located in Riyadh, Saudi Arabia.
India and the GCC:
- Largest regional trading partner: The GCC is India's most significant regional trading bloc. Bilateral trade (FY 2023-24):
- Total trade: USD 161.59 billion.
- India’s exports: USD 56.3 billion.
- India’s imports: USD 105.3 billion.
- The UAE is India's 3rd largest trading partner and 2nd largest export destination.
- Workforce and Remittances: Approximately 8.9 million Indian expatriates reside in GCC countries, forming 66% of all non-resident Indians (NRIs).
- Indian expatriates contribute significantly to remittances, a vital income source for India.
4. Mitochondrial DNA Mutations and Age-Related Muscle Loss
What are Mitochondria?
- Mitochondria are membrane-bound organelles present in the cytoplasm of most eukaryotic cells,
- They are often called the "powerhouses" of the cell, due to their role in the aerobic respiration, where metabolite of glucose is utilized to yield ATP and Carbon dioxide, and oxygen is reduced to water.
- ATP is the energy currency in living organisms.
Other functions of Mitochondria:
- Regulating cell death: Control apoptosis, ensuring the maintenance of healthy tissues.
- Mitochondrial DNA (mtDNA): Contains its own DNA, which is prone to mutations that significantly affect cellular functions.
- Mitochondria are inherited exclusively from the mother via the egg cell.
Findings on the mtDNA Mutations:
- Deletion mutation’s role: Deletion mutations in mtDNA reduce its size and functionality, gradually eroding mitochondrial efficiency.
- These mutated mtDNA molecules outcompete healthy ones, leading to a decline in ATP production.
- Chimeric genes: Deletion mutations create chimeric genes by fusing different mitochondrial genes, forming abnormal sequences.
- Chimeric genes disrupt mtDNA expression, accelerating mitochondrial dysfunction and muscle degradation.
- Age-related changes: Older individuals exhibit a two-fold increase in chimeric mitochondrial mRNA, correlating with biological aging.
- Mutations also affect brain and muscle tissues, emphasizing their systemic impact on aging.
- Biomarkers for biological ageing: mtDNA deletion mutations and chimeric mRNA are key indicators of biological aging.
- Understanding these markers could pave the way for therapies to prevent or repair mutations, delaying age-related muscle loss.
5. Imaging Active Hydrothermal Vents
About Hydrothermal Vents:
- Hydrothermal vents are underwater hot springs near tectonic plate boundaries, expelling hot water and minerals from beneath the Earth's crust into the ocean.
- They were first identified in 1977 near the Galapagos Islands, Ecuador.
- Formation:
- Cold seawater (around 2°C) seeps through fissures in the oceanic crust near tectonic activity,
- The water then contacts hot magma, heating to temperatures up to 370°C or higher,
- Superheated water then resurfaces as mineral-rich hydrothermal fluids, forming vents and plumes.
- Types:
- Black Smokers: Emit particle-laden fluids, primarily containing iron sulfides, forming black chimney-like structures
- White Smokers: Emit fluids rich in barium, calcium, and silicon, forming white chimneys
Significance of the Discovery for India:
- Mineral Exploration: Enhances India's capacity to explore and utilize deep-sea hydrothermal sulfide fields, vital for securing mineral resources.
- Support for Samudrayaan Mission: The findings strengthen India’s ambitious Samudrayaan Mission, focusing on mineral extraction from the deep ocean.
- Microbial Research: Offers insights into chemosynthetic organisms, broadening knowledge of deep-sea biology and potential biotechnological applications.
About Red Panda:
- Scientific Name: Ailurus fulgens
- It is a small arboreal mammal found in the forests of India, Nepal, Bhutan, and the northern mountains of Myanmar and southern China.
- It thrives best at 2,200-4,800 m in mixed deciduous and conifer forests with dense understories of bamboo, though red panda evidences have also been found at 1800 m.
- In India, it is found in Sikkim, Arunachal Pradesh and Darjeeling and Kalimpong districts of West Bengal.
- Almost 50% of the red panda’s habitat is in the Eastern Himalayas.
- It is the state animal of Sikkim.
- It uses its long, bushy tails for balance and to cover them in winter, presumably for warmth.
- It is considered an indicator speciesfor ecological change.
- It is the size of a house cat and is famous for its cute face and adorable defense stance.
- The loss of nesting trees and bamboo is causing a decline in red panda populations across much of their range because their forest home is being cleared.
- Conservation Status:
- IUCN Red list: Endangered
- CITES:Appendix I
- Wildlife Protection Act 1972: Schedule I
Padmaja Naidu Himalayan Zoological Park:
- It is located West Bengal.
- It hosts the country’s most successful conservative breeding programme for red pandas.
- The planned conservation breeding programme began in 1986 as a part of the Global Captive Breeding Masterplan.
About Mammoth:
- Mammoths are member of an extinct species belongs to elephantid genus Mammuthus.
- They lived from the Pliocene epoch (from around 5 million years ago) into the Holocene at about 4,000 years ago.
- They existed in Africa, Europe, Asia, and North America.
- Features:
- The various species of mammoth were commonly equipped with long, curved tusks.
- They evolved a suite of adaptations for arctic life, including morphological traits such as small ears and tails to minimize heat loss, a thick layer of subcutaneous fat, long thick fur, and numerous sebaceous glands for insulation.
- They also had large brown-fat hump like deposit behind the neck that may have functioned as a heat source and fat reservoir during winter.
- Mammoths are more closely related to living Asian elephants than African elephants.
- IUCN Status: Extinct
Key facts about Permafrost:
- It is any ground—from soil to sediment to rock—that has been frozen continuously for a minimum of two years and as many as hundreds of thousands of years.
- It can extend down beneath the earth’s surface from a few feet to more than a mile, covering entire regions, such as the Arctic tundra, or a single, isolated spot, such as a mountaintop of alpine permafrost.
- It can be found on land and below the ocean floor.
About Golden Visa programme:
- It is a residence by investment plan, which grants temporary residency to foreign nationals in exchange for a significant donation or investment in real estate, business, or other fields is known as a "Golden Visa."
- High-net-worth individuals (HNWIs) often physically relocate to favorable jurisdictions through golden visa schemes, granting them complete legal residency rights, including the facility to live, work, study, and receive healthcare in that nation.
Spain’s Golden Visa programme:
- Introduced in 2013, it allowed non-European Union citizens to obtain residency permits by investing a minimum of €500,000 in Spanish real estate.
- Reasons for terminating the programme
- It cited the need to address rising property prices and ensure housing availability for local citizens, particularly in major cities.
- The programme was used for money laundering and tax evasion.
About Lesotho:
- It is an enclaved nation located within the territory of South Africa.
- It has a population of about 2.3 million and a per capita Gross Domestic Product (GDP) of $878.0 in 2023. It is classified as a lower middle-income country.
- It is primarily highlands, with its lowest point 1,400 meters above sea level. It is the only independent state in the world that lies entirely above 1,400 m in elevation.
- Thabana Ntlenyana, at 3,482 metres, is the highest mountain of Lesotho and the southern Africa.
- The Orange River at about 2,100 km in length is one of the longest rivers in Africa. It rises in the Lesotho Highlands as the Sinqu River.
- Previously a British protectorate, it gained its independence in 1966.
- It is a constitutional monarchy, ruled by a King as Head of State, and governed by a 33-member Senate and a 120-member National Assembly.
- Maseruis the capital and largest city of Lesotho.
About Viksit Panchayat Karmayogi Initiative:
- It is part of the broader ‘Prashasan Gaon Ki Aur’ campaign.
- It aims to enhance the capacity and competence of Panchayati Raj Institutions (PRIs) by equipping elected representatives and officials with the tools and knowledge required for effective governance and participatory planning.
- It is currently piloted in Odisha, Assam, Gujarat, and Andhra Pradesh.
- The initiative leverages e-learning platforms, AI-powered chatbots, and mobile apps to bridge knowledge gaps and enhance service delivery.
- This program aligns with the government’s broader mission to decentralize governance and foster participatory decision-making at the grassroots level.
- The initiative is expected to create scalable models of citizen-centric governance, enabling PRIs to drive equitable and sustainable development across rural India.
Other initiatives:
- New dashboard on the iGOT Karmayogi platform:
- It is designed to empower ministries, departments, and state administrators with advanced tools to monitor user registrations, course completions, and overall progress in capacity-building efforts.
- With customizable views and robust data filtration capabilities, the dashboard provides detailed insights to improve decision-making and optimize training initiatives.
- CPGRAMS Annual Report 2024:
- It provides a comprehensive review of the Centralized Public Grievance Redress and Monitoring System.
- The report showcases key achievements, including the resolution of over 25 lakh grievances annually and the implementation of the Grievance Redressal Assessment and Index (GRAI).